A landmark contribution to poultry science--Immunological function of the bursa of Fabricius.
نویسندگان
چکیده
The article "The bursa of Fabricius and antibody production" by Bruce Glick, Timothy S. Chang, and R. George Jaap first demonstrated the role of the bursa in immune development. Birds, including chickens, possess a peculiar organ, the bursa of Fabricius. The organ was recognized for more than 300 yr before its function was described in 1956. Discovery of the bursa as an essential component of the immune response began by accident. Removal of the bursa, bursectomy, during the rapid growth period diminished the antibody response to Salmonella. A paper describing this exceptional finding was initially rejected by Science and ultimately published in Poultry Science. This revelation triggered sequential events leading to the understanding of the dichotomy of the immune response. Additional work in multiple laboratories over many years revealed fundamental immune mechanisms attributable to the bursa. Understanding those mechanisms advanced agricultural and biomedical science.
منابع مشابه
Effect of Feeding Oak Acorn on Expression of IL-2, IL-13 and IFN-γ Genes in Bursa Fabricius Tissue of Broiler Chickens (Short Communication)
Today, the use of oak as a replacement feed in poultry diets is well documented. However, oak contains polyphenol compounds (tannins) as antinutrient factors resulted in limited usage in the poultry rations. Generally, consumption of feeds containing tannin could affect gene expression level of immune system. Therefore, the aim of this study was to investigate the effect of different levels of ...
متن کاملEffects of Microwave-Treated Drinking Water on Growth and some Physiological Characteristics of Japanese Quail (Coturnixcoturnix japonica)
Present preliminary scientific trial was designed to investigate of microwave effects on Japanese quails as an animal model. Thirty six three days-old quail chicks were randomly divided into 3 experimental groups and received: A) un-treated tap water, B) tap water boiled by electrical heater and then cooled and C) tap water treated by microwave oven and then cooled. The whole experimental perio...
متن کاملProposed bursa of Fabricius weight to body weight ratio standard in commercial broilers.
Several causes may induce change and atrophy in the bursa of Fabricius (BF). Databases on BF standards are available from published studies, however, updated references are needed to adjust the BF standards to present changes in highly specialized broiler genetic lines. The aim of this study was to evaluate BF-related measurements (weight and dimensions) under controlled conditions that would m...
متن کاملInfluence of dietary arginine concentration on lymphoid organ growth in chickens.
In vivo effects of graded dietary levels of arginine on the body and lymphoid organs were investigated using Cornell K strain chickens of the B15/B15 haplotype. Two-week-old birds were fed an arginine-deficient basal diet (0.53% arginine) supplemented with additional arginine (up to 1.0% L-arginine to the diet). At four weeks of age, body weight, lymphoid organ weight, and concentrations of ami...
متن کاملEffect of plant extracts derived from thyme on male broiler performance.
The effect of dietary thyme-oil extract (TOE) supplementation on immune functions of broilers were assessed by feeding graded levels (50, 100, 200, or 400 ppm) of TOE to male broiler chicks during a 42-d feeding trial compared with negative- or positive-control diets. Dietary control treatments included a negative-control diet with no feed-additive supplementation and 2 positive-control groups ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Poultry science
دوره 88 4 شماره
صفحات -
تاریخ انتشار 2009